Systemic Hypertension

  • Persistently elevated blood pressure with or without anti-hypertensive treatment
  • In acute stage, principal ophthalmic manifestations: narrowed retinal arterioles, cotton wool spots, flame-shaped hemorrhages, retinal infarction, optic disc edema (reflecting vessel leakage, occlusion)
  • In chronic stage, principal ophthalmic manifestations: arteriovenous nicking, copper-wiring and silver-wiring (reflecting thickened, stiff arteriolar walls)
  • No visual symptoms unless cotton wool spots or hemorrhages very numerous or large, or located at or near fovea
  • Cotton wool spots: feathery white patches in retinal surface layer that block view of underlying retina
  • Flame-shaped hemorrhages: slender red streaks in retinal surface layer that block view of underlying retina
  • Retinal infarcts: areas of gray turbidity
  • Choroidal infarcts: areas of retinal pigment epithelial atrophy
  • Optic disc edema: elevated and blurred optic disc margins, reflecting leakage of optic disc capillaries; not seen unless retinal abnormalities are severe
  • Arteriovenous nicking: indentation and deflection of retinal veins as they cross stiff retinal arterioles
  • Copper-wiring: shift in color of retinal arterioles from red to orange, as walls thicken and stiffen
  • Silver-wiring: shift in color of retinal arterioles from red to white, as thickened wall obliterates blood column
  • Refer patient with newly blurred vision in acute severe systemic hypertension urgently to ophthalmologist
  • Refer patient without visual symptoms in acute or chronic systemic hypertension to ophthalmologist non-urgently to determine impact of hypertension on eyes as visible target organs
  • If blood pressure is controlled, then...
  • Hemorrhages spontaneously disappear within weeks
  • Cotton wool spots disappear within weeks, leaving behind bothersome scotomas only if cotton wool spots were large or near fovea
  • Optic disc edema disappears within weeks
  • Retinal infarct turbidity disappears, leaving behind retinal atrophy and scotoma