Wet Age-Related Macular Degeneration

  • Form of macular degeneration marked by...
  • Leakage of serum or blood into fovea from choroidal new blood vessels that have burrowed into retina ("choroidal neovascularization"), which causes...
  • Reduced visual acuity and distorted vision ("metamorphopsia")
  • Accounts for up to 20% of cases of age-related macular degeneration
  • Periodic intravitreous injection of  inhibitors of vascular endothelial growth factor (VEGF) is effective in retarding and sometimes restoring vision loss
  • Other possibly effective treatments include thermal laser photocoagulation, photodynamic therapy, and supplementation with zinc and antioxidant vitamins
  • Retinal and choroidal degenerations, inflammations, infections, tumors, and trauma
  • Refer non-urgently if this is incidental finding
  • Refer urgently if associated with new vision loss
  • Instruct patients to report to their ophthalmologist immediately if they notice sudden development of warped or blurred vision because these symptoms signal subfoveal bleeding
  • Traditional photocoagulation treatments, which modestly reduce pace of vision loss but do not restore vision, have mostly given way to...
  • Periodic injections of VEGF inhbitors into vitreous cavity (yes, really!), which slow and sometimes reverse vision loss
  • Stopping smoking and taking daily combination tablet of vitamin C 500mg, vitamin E 400 IU, zinc oxide 80mg, cupric oxide 2mg, and beta carotene 15mg reduce progression of vision loss