Bisphosphonates

  • Medications that inhibit bone resorption and are used to prevent osteoporosis
  • Most commonly used medications: pamidronate, alendronate, risedronate
  • Most common ophthalmic side effects: acute conjunctivitis, anterior uveitis, orbital myositis, episcleritis, scleritis within days to weeks of starting medication
  • Eye pain
  • Blurred and double vision
  • Red eye
  • Lid swelling
  • Proptosis
  • Anticipate these ophthalmic manifestations
  • Refer to ophthalmologist urgently
  • Discontinuing medication brings about recovery, but...
  • Treatment with topical or oral corticosteroid or nonsteroidal anti-inflammatory drug (NSAID) often needed to hasten relief