These brown mounds on the iris are characteristic of which condition?
Incorrect. Tuberous sclerosis causes retinal lesions; it does not affect the iris. Try again!
Incorrect. Lupus erythematosus causes cotton wool spots, flame-shaped hemorrhages, and retinal arteriolar occlusions. It does not cause the iris abnormalities you see here. Try again!
Incorrect. Good guess! Sarcoidosis can cause granulomatous iris nodules on the pupillary margin (“Koeppe nodules”) and in the mid-iris stroma (“Busacca nodules”). Koeppe and Busacca nodules could resemble those that you see here, but would be accompanied by other manifestations of anterior uveitis (cell and flare in the anterior chamber). Try again!
Correct. Neurofibromatosis Type 1, an autosomal dominant disorder that often causes tumors throughout the body, usually shows these iris hamartomas called Lisch nodules reliably in children who are above age 10 years. The eye will not be inflamed. But there may be gliomas of the optic nerve and optic chiasm.