A 5 year old child is being treated with vigabatrin for refractory seizures. A possible ophthalmic complication is:
Incorrect. Keratopathy is not a complication of vigabatrin. Moreover, keratopathy would never cause these markedly constricted visual field defects. Try again!
Incorrect. Cataract is not a complication of vigabatrin. Moreover, cataract would never cause these markedly constricted visual field defects. Try again!
Correct. Vigabatrin can cause visual field constriction, as indicated in the above figure. The field constriction is caused by toxicity to peripheral bipolar retinal cells, interfering with visual signal transmission. Most patients who take this medication for refractory seizures are so neurologically impaired that they do not report the visual impairment. For that reason, ophthalmic monitoring must be performed.
Incorrect. Optic neuropathy is not a complication of vigabatrin. Try again!