Cornea Clinical Trials

To learn more about clinical trials on treatments for eye disease please call or email the contact for the specific study below.

For a longer list of studies needing volunteers throughout the U-M Health System, please go to UMClinicalStudies.

On this page:

 

Studies that are Open and Enrolling

Title:  A prospective, multicenter post-approval study of Visioncare’s implantable miniature telescope (by Dr. Isaac Lipshitz) in patients with bilateral severe to profound central vision impairment associated with end-stage age-related macular degeneration (IMT-PAS-01)

IRB Number: HUM00089615
Status: Open/Enrolling

The purpose of the IMT-PAS-01 study is to evaluate the safety of the intraocular telescope for the treatment of bilateral end-stage age-related macular degeneration under commercial conditions following U. S. market approval.

Eligibility:

  • Must be 65 years of age or older
  • Must be a candidate to receive the Implantable Miniature Telescope Study Contact:

Study Contact:

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Title: Cross-Sectional Study of the Prevalence of TGFBI Corneal Dystrophies in a North American Population (Avellino-Prevalance)

IRB Number: HUM00111521
Status: Open/Enrolling

This study is designed to gather information about the number of people in the United States and Canada who carry a gene for a family of rare inherited eye conditions called TGFBI corneal dystrophy.   People who have certain types of corneal dystrophy should not have LASIK.   By participating in this study, you will be tested for certain corneal dystrophies, and will have the option to learn the results of your test.

Eligibility:

  • 18 years of age or older
  • Have a diagnosis of keratoconus or corneal ectasia
  • Willing to provide up to 5 buccal (cheek) swabs

Study Contact:

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Title: Comprehensive ocular telemedicine assessment

IRB Number: HUM00072885

The purpose of this research is to identify methods that improve the usefulness, reliability, and validity of ophthalmic photographs that test for eye disease, vision, eye care questionnaire to help identify visual problems, increase eye care access in underserved communities, and provide a way to set up programs for eye disease screening.

Eligibility:

Must be 18 years of age or older with any of the following eye conditions:

  • Diabetic eye disease
  • Inflammatory Orbital Disease
  • Eyelid Tumors
  • Corneal Lesions
  • Ocular Surface tumors, scars, infections, inflammatory diseases, and swelling
  • Eye Movement Disorders
  • Glaucoma

Study Contact:

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Ongoing Studies

Title: Corneal preservation time study (CPTS)

IRB Number: HUM00059287

The CPTS is a randomized, controlled clinical trial examining the impact of preservation time on graft failure and endothelial cell density following EK. 
The primary objectives of the study are:

  • To determine if the 3-year graft failure rate following EK performed with donor corneas with a preservation time of 8 to14 days is non-inferior to the failure rate when donor corneas with a preservation time of 7 or fewer days are used.
  • To determine if the central corneal endothelial cell density 3-years after EK is related to preservation time.
  • To evaluate the effect of donor, operative and postoperative factors on graft failure and endothelial cell density three years following EK.

The study has been designed so that the surgeons and eye banks can follow and provide their usual surgical and post-operative procedures and care to study participants with the exception of assignment of donor tissue.  Study eyes will be randomly assigned to receive a donor cornea from preservation date to surgery date of 8 to 14 days or a donor cornea from preservation date to surgery date of 7 or fewer days, with a comparable death to preservation time for both groups. Surgeons and study participants are masked to time from preservation to surgery.

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Title: Long-term outcomes after laser in situ keratomileusis (LASIK): mechanical microkeratone vs. femtosecond laser

IRB Number: HUM00049051

To assess long term outcomes of patients who underwent laser in situ keratomileusis (LASIK) with microkeratome and femtosecond laser flaps. LASIK is the most common corneal refractive surgery performed for correction of myopia (nearsightedness). There are few studies that have been performed to evaluate long-term outcomes after LASIK. Volunteers were eligible for enrollment into the study if they have had LASIK surgery for correction of myopia or myopic astigmatism at the Kellogg Eye Center with either the microkeratome or femtosecond laser for LASIK flap creation between 5-10 years prior.

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Title: Dry eye assessment and management (DREAM)

IRB Number: HUM00086107

The DREAM study will evaluate the effectiveness and safety of using supplements of omega-3-fatty acids to treat the symptoms of moderate to severe dry eye disease.

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Title: Eye Disease Detection by Avellino DNA tests (Avellino-KCN)

IRB Number: HUM00105945

This study is designed to discover any mutations or changes in the DNA associated with keratoconus. Avellino lab will be developing tests to identify these mutations in order to provide genetic information of eye diseases to physicians in addition to the routine examinations.

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Title: Neovascularization study

IRB Number: HUM0006281

This study determined specific corneal neovascularization (CN) patterns in human corneal allograft recipients to determine the characteristics that worsen the prognosis for graft survival. We  tested the hypothesis that specific characteristics of CN are prognostic for corneal allograft rejection.  Confocal biomicroscopy (CBM) was compared to the current clinical standard of slit lamp biomicroscopy as well as to a more definitive, but more invasive method of vessel quantification, corneal fluorescein angiography (CFA).

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Title: The pathogenesis of idiopathic dry eyes

IRB Number: HUM00013091

To evaluate patients with dry eye symptoms for abnormalities in sensory processing  to ultimately learn about possible relationships between dry eye symptoms and fibromyalgia in order to better understand and treat these conditions.

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Title: In vivo corneal confocal microscopy for non-invasive assessment of diabetic peripheral neuropathy (DPN)

IRB Number: HUM00042377

This study aimed to assess and quantify diabetic peripheral neuropathy through in vivo confocal microscopy of the cornea in 4 groups of volunteers: diabetic patients with known microvascular disease, newly diagnosed diabetic patients, healthy controls and  non-diabetic patients with chronic pain. The proposed research aimed to establish in vivo confocal microscopy as a non-invasive, quantitative, and diagnostic method to evaluate human corneal nerves.

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Last Modified: Wednesday, 16-Nov-2016 13:52:40 EST