Basic Research

Biochemistry, Pharmacology, and Molecular Biology

  • Steven F. Abcouwer, Ph.D.
    Role of glucose-responsive thioredoxin-interacting protein (Txnip) in neuroprotection and neurodegeneration during retinal diseases including diabetic retinopathy. Mechanisms of neuroprotection by alpha2A-adrenergic receptor agonists during retinal ischemia and reperfusion and diabetes.
  • Robin Ali Ph.D., FMedSci
    Pathophysiology of inherited retinal degeneration and age-related macular degeneration
  • David A. Antonetti, Ph.D.
    Investigations into the formation and loss of the blood-brain and blood-retinal barrier in normal vascular biology, diabetes and cancer
  • Cagri G. Besirli, M.D., Ph.D.
    Molecular mechanisms of photoreceptor cell death and survival during periods of retinal stress
  • Monte A. Del Monte, M.D.
    Basic studies on the etiology and treatment of diabetic retinopathy, mechanisms of hereditary eye disease
  • Raymond S. Douglas, M.D., Ph.D.
    Immunologic mechanisms of thyroid eye disease, with a focus on understanding fundamental molecular processes and applying these findings to clinical trials.
  • Susan G. Elner, M.D.
    Inflammatory processes of the retina and retinal pigment epithelium
  • Victor M. Elner, M.D., Ph.D.
    Molecular targets of retinal inflammation and degeneration
  • Patrice E. Fort, Ph.D., M.S.
    Identifying and understanding mechanisms of retinal cell death that occur in neurodegenerative disorders such as diabetes.
  • Thomas W. Gardner, M.D., M.S.
    Pathogenesis and treatment of diabetic retinopathy and alterations in growth factor signaling
  • Alon Kahana, M.D., Ph.D.
    The biology and developmental genetics of extraocular muscles and neural crest-derived stem cells in the orbit and their importance in orbital cancer, craniofacial syndromes, congenital eye disorders and thyroid-related eye disease.
  • Cheng-mao Lin, Ph.D.
    Mechanisms of ocular inflammation and angiogenesis in neurodegeneration and vascular pathophysiology of retina during diabetes
  • Xuwen Liu, M.D., Ph.D.
    Molecular mechanisms by which the tight junctions contribute to control of vascular permeability and blood vessel growth and identifying ways to block or reverse vascular dysfunction in diabetic retinopathy.
  • Sayoko E. Moroi, M.D., Ph.D.
    Molecular pharmacology of glaucoma medications; aqueous humor dynamics; wound healing
  • Rajesh C. Rao, M.D.
    Transcriptional control of retinal cell identity and small molecule directed reprogramming of cells
  • Terry J. Smith, M.D.
    Molecular mechanisms underlying the pathogenesis of thyroid-associated ophthalmopathy, extracellular matrix, cell signaling and gene expression.
  • Debra A. Thompson, Ph.D.
    Molecular studies of retinal pigment epithelium function and regulation
  • Dongli Yang, M.D., Ph.D.
    Molecular mechanisms of retinal inflammation and degeneration
  • David N. Zacks, M.D., Ph.D.
    Mechanisms of retinal cell death during retinal diseases such as retinal detachments, age-related macular degeneration and ocular inflammatory disease

Cell and Developmental Biology

  • Steven F. Abcouwer, Ph.D.
    Functions and reactions of the retinal innate immune system (microglia) in health and disease.
  • Robin Ali Ph.D., FMedSci
    Retinal development; directional differentiation of stem cells
  • Brenda L. Bohnsack, M.D., Ph.D.
    Genetic regulation of neural crest stem cells in ocular development
  • Monte A. Del Monte, M.D.
    Cell biology of ocular tissue, especially human retinal pigment epithelium , tissue culture models of ocular diseases
  • Victor M. Elner, M.D., Ph.D.
    Cell-cell receptor and cytokine-mediated communication; inflammatory and scarring mechanisms; intracellular signaling pathways
  • Patrice E. Fort, Ph.D., M.S.
    Identifying and understanding mechanisms of retinal cell death that occur in neurodegenerative disorders such as diabetes.
  • Philip J. Gage, Ph.D.
    Genetics of eye development and disease; mouse models
  • Peter F. Hitchcock, Ph.D.
    Neural stem cells, retinal growth and development, injury-induced neurogenesis and neuronal regeneration
  • Alon Kahana, M.D., Ph.D.
    The biology and developmental genetics of extraocular muscles and neural crest-derived stem cells in the orbit and their importance in orbital cancer, craniofacial syndromes, congenital eye disorders and thyroid-related eye disease.
  • Rajesh C. Rao, M.D.
    Retinal and central nervous system stem cell differentiation and reprogramming: induced pluripotent stem cells, derivation of photoreceptors and retinal pigment epithelium from endogenous and exogenous sources of stem, progenitor and differentiated cells

Genetics

  • Robin Ali Ph.D., FMedSci
    Gene therapy for treatment of inherited retinal degeneration
  • Brenda L. Bohnsack, M.D., Ph.D.
    Genetics of infantile and childhood glaucomas and congenital eye diseases
  • John R. Heckenlively, M.D.
    Molecular identification of hereditary disease processes; autoimmune retinopathies; mouse models of eye diseases; phenotype-genotype correlations
  • Alon Kahana, M.D., Ph.D.
    The biology and developmental genetics of neural crest-derived tissues in the orbit and their importance in orbital tumors and thyroid-related eye disease
  • Sayoko E. Moroi, M.D., Ph.D.
    Pharmacogenetics; genetics of glaucoma
  • Hemant S. Pawar, Ph.D.
    Genetics of primary open-angle glaucoma and angle-closure glaucoma
  • Rajesh C. Rao, M.D.
    Epigenetic regulation of neurogenesis, metaplasia, scarring, apoptosis, gliosis
  • Julia E. Richards, Ph.D.
    Molecular genetic studies of glaucoma and other hereditary eye diseases; mapping of disease loci, positional candidate and candidate gene approaches to identification of disease genes, genotype-phenotype studies of glaucoma loci, expression profiling of ocular tissues; studies of primary open-angle glaucoma, secondary and developmental glaucomas, other traits such as nanophthalmos, corneal dystrophies, or syndromes associated with glaucoma
  • Frank W. Rozsa, Ph.D.
    Expression profile studies of trabecular meshwork and other cell types relevant to understanding loss of intraocular pressure homeostasis in glaucoma; studies of the role of differential gene expression events in glaucoma risk factors including aging
  • Debra A. Thompson, Ph.D.
    Molecular genetic studies of the role of defects in vitamin A metabolism as they relate to causes and treatment of retinal degeneration

Neuroscience

  • Steven F. Abcouwer, Ph.D.
    Role of retinal glial cells in the neuroinflammatory response to retinal diseases including diabetic retinopathy. Role of glucose-responsive thioredoxin-interacting protein (Txnip) in neuroprotection and neurodegeneration during retinal diseases including diabetic retinopathy. Mechanisms of neuroprotection by alpha2A-adrenergic receptor agonists during retinal ischemia and reperfusion and diabetes.
  • Robin Ali Ph.D., FMedSci
    Functional connectivity in the retina and visual cortex following gene and cell therapy
  • Patrice E. Fort, Ph.D., M.S.
    Identifying and understanding mechanisms of retinal cell death that occur in neurodegenerative disorders such as diabetes.
  • Daniel G. Green, Ph.D.
    Electrophysiology of normal and abnormal rodent retinas
  • Cheng-mao Lin, Ph.D.
    Mechanisms of ocular inflammation and angiogenesis in neurodegeneration and vascular pathophysiology of retina during diabetes
  • Donald G. Puro, M.D., Ph.D.
    Patch-clamp studies of retinal cells
  • Rajesh C. Rao, M.D.
    Mechanisms of retinal gliosis, proliferation, fibrosis, apoptosis and neurogenesis from stem cells
  • Kwoon Y. Wong, Ph.D.

    Physiology of intrinsically photosensitive retinal ganglion cells ("ipRGCs"), which regulate non-image-forming visual responses including the pupillary light reflex and circadian photoentrainment

Physiology and Biophysics

  • Victor M. Elner, M.D., Ph.D.
    Inflammatory and apoptotic processes of the eye; imaging of metabolism and cellular dysfunction of cells, animal models, and humans
  • Bret A. Hughes, Ph.D.
    Function and regulation of ion channels and transporters in the retinal pigment epithelium
  • Howard R. Petty, Ph.D.
    Inflammatory processes within the eye; microscopic and other imaging techniques
  • Donald G. Puro, M.D., Ph.D.
    Role of ion channels in retinal glial cell function
  • Kwoon Y. Wong, Ph.D.
    Physiology of intrinsically photosensitive retinal ganglion cells (“ipRGCs”), which regulate non-image-forming visual responses including the pupillary light reflex and circadian photoentrainment

Vascular Biology

  • Robin Ali Ph.D., FMedSci
    Development of gene therapy to treat ocular neovascularization
  • David A. Antonetti, Ph.D.
    Investigations into the formation and loss of the blood-brain and blood-retinal barrier in normal vascular biology, diabetes and cancer
  • Thomas W. Gardner, M.D., M.S.
    Pathogenesis and treatment of diabetic retinopathy and alterations in growth factor signaling
  • Cheng-mao Lin, Ph.D.
    Mechanisms of ocular inflammation and angiogenesis in neurodegeneration and vascular pathophysiology of retina during diabetes
  • Xuwen Liu, M.D., Ph.D.
    Molecular mechanisms by which the tight junctions contribute to control of vascular permeability and blood vessel growth and identifying ways to block or reverse vascular dysfunction in diabetic retinopathy.
  • Donald G. Puro, M.D., Ph.D.
    Physiology and pathobiology of retinal microvessels; implications for diabetic retinopathy
  • Rajesh C. Rao, M.D.
    Small molecule inhibition of angiogenesis
Last Modified: Monday, 14-Mar-2016 15:52:35 EDT