April 30, 2009
Kellogg Eye Center at ARVO 2009
Over 50 research faculty and investigators from the University of Michigan Department of Ophthalmology and Visual Sciences will present papers or posters at the annual meeting of the Association for Research in Vision and Ophthalmology. Abstracts and additional details are available at www.arvo.org.
Educational Course
Session: Cell Signaling Pathways in Ocular Development and Tumor Formation
Saturday, May 2, 2009 8:30 am - 4:30 pm
Clinical manifestations of hedgehog signaling abnormalities: Basal Cell Nevus Syndrome
A. Kahana
Department of
Ophthalmology and Visual Sciences, University of
Michigan, Ann Arbor, MI
Keynote Address
Fifth Annual ARVO/Pfizer Ophthalmics Research Institute
Friday, May 1, 2009
Epidemiology of the Corneal Dystrophies - Defining the Scope of the Problem - Prevalence and Financial Impact
D.C. Musch
Department of
Ophthalmology and Visual Sciences, University of
Michigan, Ann Arbor, MI
Moderator
Poster Session: Retina-Macular Diseases Except AMD
Sunday, May 3, 2009, 11:15 am - 1:00 pm
M.W. Johnson
Department of
Ophthalmology and Visual Sciences, University of
Michigan, Ann Arbor, MI
Poster Session: Retina-Retinal Dystrophy
Thursday, May 7, 2009 1:15 pm - 3:00 pm
J.R. Heckenlively
Department of
Ophthalmology and Visual Sciences, University of
Michigan, Ann Arbor, MI
Paper Session
Session: Biochemistry & Molecular Biology-Genetics and Biochemistry of
Animal Models of Retinal Diseases
Monday, May 4, 2009, 1:45 pm - 3:30 pm
New Insight Into the Function of the Leber Congenital Amaurosis-Causing Gene RDH12
A. Kasus-Jacobi1, D.A. Thompson2, M.A. Babizhayev3,4, L.D. Marchette1
1Ophthalmology, Univ of Oklahoma Hlth Sci Ctr, Oklahoma City, OK; 2Department of
Ophthalmology and Visual Sciences, University of
Michigan, Ann Arbor, MI; 3Moscow Helmholtz Research Institute of Eye Disorders, Moscow, Russian Federation; 4Innovative Vision Products, Inc., County of New Castle, DE
Session: Biochemistry & Molecular Biology-Genetics and Biochemistry of
Animal Models of Retinal Diseases
Monday, May 4, 2009, 1:45 pm - 3:30 pm
Wnt-frizzled Signaling in
Retinal Optic Disc Formation and Adult Retina
Degeneration
C. Liu1, Y. Wang2A, A. Rattner2A,
J. Nathans2A,2B, A. Swaroop1,3
1Neurobiology
Neurodegeneration & Repair Laboratory (N-NRL),
National Eye Institute, Bethesda, MD; AMolecular
Biology and Genetics, BHoward Hughes Medical
Institute, 2Johns Hopkins University, Baltimore, MD; 3Department of
Ophthalmology and Visual Sciences, University of
Michigan, Ann Arbor, MI
Session: Factors Influencing Information Flow Through the Retina
Monday, May 4, 2009 1:45 pm - 3:30 pm
AMPA- and NMDA-receptor-mediated Responses in Off Alpha Retinal Ganglion Cells Encode Different Ranges of Visual Contrast
M. Manookin, M. Weick, J.B. Demb
Department of Ophthalmology and Visual Sciences, University of Michigan, Ann Arbor, MI
Session: Glaucoma-Progression in Glaucoma
Tuesday, May 5, 2009 8:30 am - 10:15 am
Longitudinal Change in Mood Indicators in the Collaborative Initial Glaucoma Treatment Study (CIGTS)
H.D. Jampel1, K.D. Frick2, N.K. Janz3, D.C. Musch4, Collaborative Initial Glaucoma Treatment Study
1Ophthalmology, Johns Hopkins Wilmer Eye Inst, Baltimore, MD; 2Health Policy and Management, Bloomberg School of Public Health of Johns Hopkins University, Baltimore, MD; 3Department of Health Behavior and Health Education, University of Michigan School of Public Health, Ann Arbor, MI; 4Department of
Ophthalmology and Visual Sciences, University of
Michigan, Ann Arbor, MI
Session: Eye Movements, Strabismus, Amblyopia &
Neuro-Ophthalmology-Extraocular Muscles and
Nystagmus
Tuesday, May 5, 2009, 1:45 pm - 3:30 pm
Retinoic Acid Regulates
Orbital Development and Extraocular Muscle
Organization in Zebrafish
A. Kahana1, F. Elsaeidi1,
D. Demiri1, B.L. Bohnsack1, A.-A. Calinescu1, D.
Goldman2
1Department of
Ophthalmology and Visual Sciences, University of
Michigan, Ann Arbor, MI; 2Biochemistry, Molecular and
Behavioral Neuroscscience Institute, Univ of Michigan,
Ann Arbor, MI
Session: Biochemistry & Molecular Biology-Photoreceptors and Transduction
Wednesday, May 6, 2009, 3:45 pm - 5:30 pm
Integrity and Ciliary Localization
of the RPGR-SMC Protein Complex Are Critical
for Normal Photoreceptor Function
C.A. Murga-Zamalloa1, R.A. Rachel2, A. Swaroop2, H. Khanna1
1Department of
Ophthalmology and Visual Sciences, University of
Michigan, Ann Arbor, MI; 2Neurobiology,
Neurodegeneration & Repair laboratory, National
Eye Institute, Bethesda, MD
Session: Clinical & Epidemiologic Research-Healthcare Delivery, QOL, and
Pediatrics
Thursday, May 7, 2009, 11:15 am - 1:00 pm
Development of a Decision
Analytic Model of Changes in Mean Deviation
in People With Glaucoma---A Merger of Data
From the CIGTS, OHTS, and AGIS Trials
S.M.
Kymes1, S.V. Kotak2, D.L. Lambert1, D.L. Stwalley1,
C.J. Siegried1, P.L. Lee3, D.C. Musch4, C.A. Johnson5,
J. Fain6, M.O. Gordon1
1Ophthal/Vis Science,
Washington Univ Sch of Med, St Louis, MO; 2Global Outcomes Research, Pfizer, New York, NY; 3Ophthalmology, Duke University, Durham, NC; 4Department of
Ophthalmology and Visual Sciences, University of
Michigan, Ann Arbor, MI; 5Ophthalmology and
Visual Sciences, University of Iowa, Iowa City, IA; 6Ophthalmics, Pfizer, Chicago, IL
Poster Session
Session: Angiogenesis and Antiangiogenic Drugs
Sunday, May 3, 2009, 8:30 am - 10:15 am
FGFR1 Mediates the Inhibitory Action of Octreotide in hRPE Cells
J. Mackovjak1, P. Kothary2, M. Del Monte2
1Ophthalmology, University of Michigan Medical School, Ann Arbor, MI; 2Department of Ophthalmology and Visual Sciences, University of Michigan, Ann Arbor, MI
Session: Retinal Imaging and Image Processing
Sunday, May 3, 2009, 8:30 am - 10:15 am
Unusual Autofluorescence in a Case of Cancer Associated Retinopathy (CAR)
A.H. Moosavi1, N. Okhravi2, J.B. Ruddle1, R.J. Hanson1, P.J. Foster3, J.R. Heckenlively4, C. Simpson5, G.E. Holder3
1Ophthalmology, Moorfields Eye Hospital, London, United Kingdom; 2Ophthalmology, Moorfields Eye Hospital & UCL Institue of Ophthalmology, London, United Kingdom; 3Ophthalmology, Moorfields Eye Hospital & UCL Institute of Ophthalmology, London, United Kingdom; 4Department of Ophthalmology and Visual Sciences, University of Michigan, Ann Arbor, MI; 5Pathology, Bronglais Hospital, Wales, United Kingdom.
Session: Retinal Cell Biology-Diabetic Retinopathy Mechanisms
Sunday, May 3, 2009, 8:30 am - 10:15 am
Retinal Microvascular KATP Channels:
Redox Regulation, Spermine Modulation and
Diabetic Alteration
M. Fukumoto, E. Ishizaki,
D.G. Puro
Department of
Ophthalmology and Visual Sciences, University of
Michigan, Ann Arbor, MI
Session: Clinical & Epidemiologic Research-Glaucoma
Sunday, May 3, 2009, 11:15 am - 1:00 pm
The Association Between Glaucoma
and Death
P. Newman-Casey1, J.D. Stein1, L.M.
Niziol2, B. Gillespie2, D.C. Musch3
1Department of
Ophthalmology and Visual Sciences, University of
Michigan, Ann Arbor, MI; 2School of Public Health, University of Michigan, Ann Arbor, MI; 3Department of Ophthalmology and School of Public Health, University of Michigan, Ann Arbor, MI
Session: Cornea/Retina-Laser Refractive Surgery
Sunday, May 3, 2009, 11:15 am - 1:00 pm
Dry Eyes and Corneal Sensation
After LASIK With the IntraLase® Femtosecond
Laser: Effect of Hinge Position, Hinge Angle,
and Flap Thickness
A.Y. Li1A, S. Dutta1B, D.C.
Musch1C, R. Shtein1B, S.I. Mian1B
AMedical School,
BDepartment of Ophthalmology and Visual Sciences, CEpidemiology,
1University of Michigan, Ann Arbor, MI
Session: Retinal Cell Biology/Retina-Progress in Neuroprotective Therapies for Retinal Degenerations
Sunday, May 3, 2009, 11:15 am - 1:00 pm
Müller Cell/Microglia
Interactions in CNTF-Mediated Photoreceptor
Neuroprotection
V.P. Sarthy1, W. Xu1, V. Dudley1,
M. Brooks2, R. Khanna3, J. Roger2, A. Swaroop2
1Ophthal-Feinberg Med Sch, Northwestern
University, Chicago, IL; 2Neurobiology, Neurodegeneration and Repair Lab, National Eye
Institute, Bethesda, MD; 3Department of
Ophthalmology and Visual Sciences, University of
Michigan, Ann Arbor, MI
Session: Retinal Cell Biology/Retina-Progress in Neuroprotective Therapies for Retinal Degenerations
Sunday, May 3, 2009, 11:15 am - 1:00 pm
Inhibition of Retinal Detachment Induced
Apoptosis in Photoreceptors by a
Small Peptide Inhibitor of the FasR/FasL Death
Receptor Pathway
C.G. Besirli, Q.-D. Zheng, D.N.
Zacks
Department of
Ophthalmology and Visual Sciences, University of
Michigan, Ann Arbor, MI
Session: Retina-Macular Diseases Except AMD
Sunday, May 3, 2009, 11:15 am - 1:00 pm
Anti-retinal Pigment Epithelium
Antibodies in Acute Exudative Polymorphous
Vitelliform Maculopathy
L. Koreen, S. He,
J.R. Heckenlively, M.W. Johnson
Department of
Ophthalmology and Visual Sciences, University of
Michigan, Ann Arbor, MI
Session: Eye Movements, Strabismus, Amblyopia &
Neuro-Ophthalmology/Retina-Strabismus Surgery
Sunday, May 3, 2009, 2:45 pm - 4:30 pm
Pseudo-Brown’s Syndrome
With Superior Rectus Muscle Recession: A New
Complication of Vertical Muscle Surgery
J.A.
Galvin, S.M. Archer
Department of
Ophthalmology and Visual Sciences, University of
Michigan, Ann Arbor, MI
Session: Visual Neurophysiology/Retina-Retinal Ganglion Cells: Structure,
Function & Development
Monday, May 4, 2009, 8:30 am - 10:15 am
Intrinsic Mechanisms for Contrast
Adaptation in Alpha (y-type) Retinal Ganglion
Cells
M. Weick, M.B. Manookin, J.B. Demb
Department of
Ophthalmology and Visual Sciences, University of
Michigan, Ann Arbor, MI
Session: Biochemistry & Molecular Biology-Genetics: Age-related Macular
Degeneration
Monday, May 4, 2009, 8:30 am - 10:15 am
Genome Wide Association Study
(GWAS) of Age-Related Macular Degeneration
(AMD)
A. Swaroop1A,2A, W. Chen2B, D. Stambolian3,
K.E. Branham2C, M. Othman2C, E.Y. Chew1B, J.Heckenlively2C, N. Tosakulwong4, A.O. Edwards4,
G. Abecasis2B
AN-NRL, BEpidemiology, 1NEI
NIH, Bethesda, MD; AOphthalmology and Human
Genetics, BBiostatistics, CDepartment of Ophthalmology and Visual
Sciences, 2University of Michigan, Ann Arbor, MI; 3Ophthalmology and Human Genetics, University
of Pennsylvania, Philadelphia, PA; 4Ophthalmology,
Mayo Clinic, Rochester, MN
Session: Retinal Cell Biology/Retina-RPE Biology
Monday, May 4, 2009, 1:45 pm - 3:30 pm
Effect of PEDF on Glucose
Stimulated VEGF-R2 Synthesis in Human
Retinal Pigment Epithelial Cells
D.S. Kasprick,
P.C. Kothary, M.A. Del Monte
Department of
Ophthalmology and Visual Sciences, University of
Michigan, Ann Arbor, MI
Session: Cornea-Keratoplasty
Monday, May 4, 2009, 3:45 pm - 5:30 pm
Femtosecond Laser-Assisted
Keratoplasty: A Pilot Clinical Trial
S. Dutta, R.M.
Shtein, A. Sugar, S. Mian
Department of
Ophthalmology and Visual Sciences, University of
Michigan, Ann Arbor, MI
Session: Genetics I-Biochemistry/Molecular Biology
Monday, May 4, 2009 3:45 pm - 5:30 pm
Disease-causing Copy Number Variants (CNVs) in Genes Associated With Autosomal Recessive Retinal Degeneration
S.J. Bowne1A, L.S. Sullivan1A, D.K. Wheaton2, D.G. Birch2, J.R. Heckenlively3, S.P. Daiger1A,1B
AHuman Genetics Center, BDepartment of Ophthalmology and Visual Science, 1Univ. of Texas Health Science Center, Houston, TX; 2Anderson Research Center, Retina Foundation of the Southwest, Dallas, TX; 3Department of
Ophthalmology and Visual Sciences, University of
Michigan, Ann Arbor, MI
Session: Biochemistry & Molecular Biology-Genetics
Monday, May 4, 2009, 3:45 pm - 5:30 pm
Identification of KLHL7 as a
Novel Gene for adRP
J.S. Friedman1, N. Waseem2,
M.J. Brooks1, K. Branham3, T. Hugosson4, J.R.
Heckenlively3, S.P. Daiger5, S.S. Bhattacharya2,
S. Andreasson4, A. Swaroop1,3
1NNRL, NIH/
NEI, Bethesda, MD; 2Department of Molecular
Genetics, Institute of Ophthalmology, London,
United Kingdom; 3Department of
Ophthalmology and Visual Sciences, University of
Michigan, Ann Arbor, MI; 4Department of Ophthalmology, Lund
University, Lund, Sweden; 5Human Genetics Center,
The University of Texas Health Science Center,
University of Texas, Houston, TX
Session: Biochemistry/Molecular Biology-Genetics
Monday, May 4, 2009 3:45 pm - 5:30 pm
Targeted High-Throughput DNA Sequencing for Gene Discovery in Retinitis Pigmentosa
S.P. Daiger1, S.J. Bowne1, L.S. Sullivan1, D.G. Birch2, J.R. Heckenlively3, E.A. Pierce4, L. Ding5, E.J. Sodergren5, R.S. Fulton5, G.M. Weinstock5
1Human Genetics Center, School of Public Health, Univ. of Texas Health Science Center, Houston, TX; 2Retina Foundation of the Southwest, Dallas, TX; 3Department of
Ophthalmology and Visual Sciences, University of
Michigan, Ann Arbor, MI4Scheie Eye Institute, Univ. of Pennsylvania, Philadelphia, PA; 5Genome Sequencing Center, Washington Univ., St. Louis, MO
Session: Biochemistry & Molecular Biology-Age-related Macular Degeneration
Monday, May 4, 2009, 3:45 pm - 5:30 pm
Biochemical and Functional
Studies of ARMS2, A Mitochondrial Protein
Strongly Associated With Susceptibility to Age-Related Macular Degeneration
A. Kanda1,2, A.
Estrada-Cuzcano2, D. Hajkova3, M. Miyagi3, A.
Swaroop1,2
1NEI/NIH, Bethesda, MD; 2Department of
Ophthalmology and Visual Sciences, University of
Michigan, Ann Arbor, MI; 3Department of
Pharmacology, Case Western Reserve University,
Cleveland, OH
Session: Biochemistry/Molecular Biology-Genetics
Monday, May 4, 2009 3:45 pm - 5:30 pm
Effect of PEDF on Glucose
Stimulated VEGF-R2 Synthesis in Human
Retinal Pigment Epithelial Cells
D.S. Kasprick,
P.C. Kothary, M.A. Del Monte
Department of
Ophthalmology and Visual Sciences, University of
Michigan, Ann Arbor, MI
Session: Immunology/Microbiology-Infection and Immunity: Animal Studies
Tuesday, May 5, 2009, 8:30 am - 10:15 am
Two Mouse Models of
Autoimmune Retinopathy (AIR)
Y. Lu, L. Jia, G.
Grahek, N. Khan, J.R. Heckenlively
Department of
Ophthalmology and Visual Sciences, University of
Michigan, Ann Arbor, MI
Session: Lens-Modifying Agents Used in Cataract Surgery
Tuesday, May 5, 2009 8:30 am - 10:15 am
The Effects of Systemic α1-Adrenoreceptor Antagonists on Pupil Diameter
A. Wu1, G. Wilkes2, J.I. Finkelstein3A, D.C. Musch3A, J.T. Wei3B, T.M. Cooney3A
1University of Michigan Medical School, Ann Arbor, MI; 2California Pacific Medical Center, San Francisco, CA; ADepartment of Ophthalmology and Visual Sciences, BDepartment of Urology, 3University of Michigan, Ann Arbor, MI
Session: Biochemistry & Molecular Biology-Retina Biochemistry and Molecular
Biology (Non-photoreceptor)
Tuesday, May 5, 2009, 8:30 am - 10:15 am
Mertk Interactions With SH2-Domain Proteins in the Retinal Pigment
Epithelium
S.J. Shelby1A, D.A. Thompson1B
ABiological Chemistry, BDepartment of Ophthalmology and Visual
Sciences, 1University of Michigan, Ann Arbor, MI
Session: Biochemistry & Molecular Biology-Retina Biochemistry and Molecular
Biology (Non-photoreceptor)
Tuesday, May 5, 2009, 8:30 am - 10:15 am
Expression of KCNQ and KCNE Proteins in Bovine Retinal Pigment Epithelium
X. Zhang1, B.A. Hughes2
1Department of
Ophthalmology and Visual Sciences, University of
Michigan, Ann Arbor, MI; 2Department of Ophthalmology and Visual Sciences and Molecular and Integrative Physiology, University of Michigan, Ann Arbor, MI
Session: Biochemistry/Molecular Biology-Retina/RPE: Biochemistry and Molecular Biology
Tuesday, May 5, 2009, 1:45 pm - 3:30 pm
The Ras/Raf Signaling Pathway Mediates PEDF Synthesis in Human Retinal Pigment Epithelial Cells
N.N. Doshi, P.C. Kothary, M.A. Del Monte
Department of
Ophthalmology and Visual Sciences, University of
Michigan, Ann Arbor, MI
Session: Biochemistry & Molecular Biology-Retina/RPE: Biochemistry and
Molecular Biology
Tuesday, May 5, 2009, 1:45 pm - 3:30 pm
Cross-Talk Between the ERK
Kinase and Adenyl Cyclase Signaling Pathways
in Vascular Endothelial Growth Factor Synthesis
P.C. Kothary, S.K. Gupta, M.A. Del Monte
Department of
Ophthalmology and Visual Sciences, University of
Michigan, Ann Arbor, MI
Session: Biochemistry/Molecular Biology-Genotype/Phenotype: Age-related Macular Degeneration
Tuesday, May 5, 2009 1:45 pm - 3:30 pm
Localization and Functional Characterization of Mdm1 Retinal Transcript Associated With Age-Related Retinal Degeneration
N. Dobri1, K.Y. Yasumura2, M.V.R. Chavali1, B. Chang3, R. Ayyagari1
1Ophthalmology, UCSD, La Jolla, CA; 2Department of
Ophthalmology and Visual Sciences, University of
Michigan, Ann Arbor, MI; 3Jackson Laboratory, Bar Harbor, ME
Session: Retina-Inflammation, Retinitis, Endophthalmitis
Tuesday, May 5, 2009 3:45 pm - 5:30 pm
Intraocular Toxicity of Daptomycin: A Broad-spectrum Antibiotic for Drug-resistant, Gram-positive Infections
G.M. Comer1A, J.B. Miller1B, N.W. Khan1A, G. Scott1A, V.M. Elner1A, D.N. Zacks1A
ADepartment of
Ophthalmology and Visual Sciences, BSchool of Medicine, 1University of Michigan, Ann Arbor, MI
Session: Visual Neurophysiology-Electrophysiology of Retinal Disease in Animal Models
Tuesday, May 5, 2009 3:45 pm - 5:30 pm
Aberrant Slow Wave (Slow PIII) Component Superimposed on a Normal b-wave, Accounts for the Abnormal Electroretinogram in the mdxCv3 Mouse
B.R. Pattnaik1A,2, D.G. Green3, D.-A.M. Pillers1B,2
APediatrics, Ophthalmology and Visual Sci, BPediatrics, 1Univ of Wisconsin, Madison, WI; 2UW Eye Research Institute, Madison, WI; 3Department of
Ophthalmology and Visual Sciences, University of
Michigan, Ann Arbor, MI
Session: Biochemistry & Molecular Biology-Biochemistry and Molecular
Biology of Complex Genetics and
Positional Cloning
Tuesday, May 5, 2009, 3:45 pm - 5:30 pm
Interaction of RPGR With
Selected BBS Proteins Is Perturbed in Retinal
Ciliopathies
H. Khanna1, E. Oh2, A. Estrada1, S.
He1, A. Karoukis1, M. Othman1, J.R. Heckenlively1,
N. Katsanis2, A. Swaroop3
1Department of
Ophthalmology and Visual Sciences, University of
Michigan, Ann Arbor, MI; 2McKusick-Nathans Institute of Genetic
Medicine, Johns Hopkins University, Baltimore,
MD; 3Neurobiology, Neurodegeneration & Repair
Laboratory, National Eye Institute, Bethesda, MD
Session: Immunology & Microbiology-Genes, Cytokines, Immunity and
Degeneration
Tuesday, May 5, 2009, 3:45 pm - 5:30 pm
Autoimmune Disorders Are Very
Common in Family Members of Patients With
Autoimmune Retinopathy: Car, Mar, and Typical
Non-paraneoplastic Autoimmune Retinopathy
J.R. Heckenlively1, J. Oversier1, H. Ferreyra2,
T. Jayasundera1, K. Branham1
1Department of
Ophthalmology and Visual Sciences, University of
Michigan, Ann Arbor, MI; 2Ophthal, UCSD, San
Diego, CA
Session: Biochemistry & Molecular Biology-Eye Development
Wednesday, May 6, 2009, 8:30 am - 10:15 am
Midkine-a and Midkine-b
Regulates Neurogenesis and Neural
Differentiation in the Retina of Zebrafish
J. Luo,
A.-A. Calinescu, P.F. Hitchcock
Department of
Ophthalmology and Visual Sciences, University of
Michigan, Ann Arbor, MI
Session: Biochemistry & Molecular Biology-Eye Development
Wednesday, May 6, 2009, 8:30 am - 10:15 am
Determining the Mechanism
by Which PITX2 Regulates Expression of the
Downstream Effector kk2
P.J. Gage, M. Qian,
C. Kuang
Department of
Ophthalmology and Visual Sciences, University of
Michigan, Ann Arbor, MI
Session: Clinical & Epidemiologic Research-Glaucoma
Wednesday, May 6, 2009, 8:30 am - 10:15 am
Co-administration of Topical
and Oral β-blockers in Patients with Glaucoma:
Quantifying a Potentially Inappropriate Practice Pattern in a Large U.S. Managed-care Network
C. Rodarte, J.D. Stein, D.C. Musch
Department of
Ophthalmology and Visual Sciences, University of
Michigan, Ann Arbor, MI
Session: Genetics-Genotype-Phenotype Correlations
Wednesday, May 6, 2009, 8:30 am - 10:15 am
Phenotype - Genotype Correlation
in Patients With Retinal Degenerations
H.V
Gudiseva1, R.G. Weleber2, K. Branham3, A.
Villanueva4, N.B. Stover5, M. Greve6, R. Caruso7,
J.R. Heckenlively3, I.M. MacDonald8, R. Ayyagari1
1Jacobs Retina Center-Ophthal, Univ of California-San Diego, La Jolla, CA; 2Ophth & Molecular Med
Genetics, Casey Eye Institute-OHSU, Portland,
OR; 3Department of
Ophthalmology and Visual Sciences, University of
Michigan, Ann Arbor, MI; 4Ophthalmology,
Virtual Eye Care MD, Mexico City, Mexico; 5Ophthalmic
Genetics, Casey Eye Institute-OHSU, Portland, OR; 6Ophthalmology, University of Alberta, Edmonton,
AB, Canada; 7NIH, National Eye Institute, Bethesda,
MD; 8Ophthalmology, Royal Alexandra Hospital,
Edmonton, AB, Canada
Session: Retinal Cell Biology/Retina /Visual Neurophysiology-Mechanisms of Photoreceptor
Degeneration
Wednesday, May 6, 2009, 1:45 pm - 3:30 pm
Apoptosis in the nm3342 Mouse
Model of Retinal Degeneration
D.M. Wu1, J.
Zheng1, D.G. Puro1, N.L. Hawes2, B. Chang3, J.R.
Heckenlively1, D.N. Zacks1
1Department of
Ophthalmology and Visual Sciences, University of
Michigan, Ann Arbor, MI; 2Neurobiology, The Jackson Laborotory, Bar Harbor,
ME; 3Neurobiology, The Jackson Laboratory, Bar
Harbor, ME
Session: Retinal Cell Biology/Retina/Visual Neurophysiology-Mechanisms
Wednesday, May 6, 2009, 1:45 pm - 3:30 pm
Search for Interactors of
Retinal Degeneration 3 (RD3)
D.S. Krauth1,
J.S. Friedman1, A.E. Cuzcano2, A. Swaroop1
1Neurobiology Neurodegeneration & Repair, NEI/NIH, Bethesda, MD; 2Department of Ophthalmology and Visual
Sciences, and Human Genetics, University of
Michigan, Kellogg Eye Center, Ann Arbor, MI
Session: Eye Movements, Strabismus, Amblyopia &
Neuro-Ophthalmology-Amblyopia
Wednesday, May 6, 2009, 1:45 pm - 3:30 pm
The Pupil in Suppression and
Amblyopia
E.P. Herlihy1, S.M. Archer2
1Pediatric
Ophthalmology, Seattle Children’s Hospital, Seattle,
WA; 2Pediatric Ophthalmology, University of
Michigan Kellogg Eye Center, Ann Arbor, MI
Session: Retinal Cell Biology/Retina-Stem Cell II: Toward Therapy
Wednesday, May 6, 2009, 3:45 pm - 5:30 pm
Subretinal Transplantation
of Rod Precursors in the Retinal Degeneration
9 (rd9) Mouse
J. Yao1, H. Khanna1, B. Chang2,
J.R. Heckenlively1, A. Swaroop3, D.N. Zacks1
1Department of
Ophthalmology and Visual Sciences, University of
Michigan, Ann Arbor, MI; 2Department
of Ophthalmology, Jackson Laboratory, Bar Harbor,
ME; 3Neurobiology Neurodegeneration & Repair
Laboratory, National Eye Institute, Bethesda, MD
Session: Retinal Cell Biology-Diabetic Retinopathy Mechanisms
Thursday, May 7, 2009, 8:30 am - 10:15 am
The Raf Pathway Mediates Insulin
Stimulated VEGF Synthesis in Human Retinal
Pigment Epithelial Cells
J.A. Conley, P.C. Kothary,
M.A. Del Monte
Department of Ophthalmology and
Visual Sciences, University of Michigan, Ann Arbor, MI
Session: Biochemistry/Molecular Biology-Photoreceptors: Biochemistry and Molecular Biology
Thursday, May 7, 2009 8:30 am - 10:15 am
Promoter Analysis of the Genes Encoding Human and Mouse RDH11 and RDH12
K.L. Feathers1A, J.A. David1B, J.D. Chrispell1B, D.A. Thompson1A,1B
ADepartment of Ophthalmology and Visual Sciences, BBiological Chemistry, 1University of
Michigan, Ann Arbor, MI
Session: Biochemistry & Molecular Biology-Photoreceptors: Biochemistry and
Molecular Biology
Thursday, May 7, 2009, 8:30 am - 10:15 am
Genome-Wide Analysis of Target
Genes for Nrl in Developing and Mature Retina
H. Hao1, D. Kim1, M. Brooks1,2, R. Khanna2, M.
Othman2, K. Johnson3, R. Cojocaru1, A. Swaroop1
1Neurobiology, Neurodegenertion & Repair Lab, NEI,
Bethesda, MD; 2Department of
Ophthalmology and Visual Sciences, University of
Michigan, Ann Arbor, MI; 3NINDS, Bethesda, MD
Session: Biochemistry & Molecular Biology-Photoreceptors: Biochemistry and
Molecular Biology
Thursday, May 7, 2009, 8:30 am - 10:15 am
Molecular and Functional
Changes Associated With Normal Aging in
the Retina
J.R. Chang1, S.K. Parapuram2, R.
Khanna2, M. Brooks1, R. Cojocaru1, N. Khan2, J.
Nellissery1, J. Roger1, A. Swaroop1
1Neurobiology,
Neurodegeneration and Repair Laboratory, National
Eye Institute, Bethesda, MD; 2Department of
Ophthalmology and Visual Sciences, University of
Michigan, Ann Arbor, MI
Session: Anatomy & Pathology-Lymphoma and Others
Thursday, May 7, 2009, 11:15 am - 1:00 pm
Frequency of Non-diagnostic
Conjunctival Map Biopsies for Sebaceous
Carcinoma Correlates with Disease Severity and
Recurrence
I.V. Koreen, C.C. Nelson, B.R. Frueh,
V.M. Elner
Department of
Ophthalmology and Visual Sciences, University of
Michigan, Ann Arbor, MI
Session: Anatomy & Pathology-Lymphoma and Others
Thursday, May 7, 2009, 11:15 am - 1:00 pm
Non-Invasive Contrast-Enhanced Magnetic Resonance Angiography is a Useful
Tool in the Diagnosis and Treatment of Orbital
Vascular Lesions
B.L. Bohnsack1A, R.I. Cho1A, A.
Sanchez-Castellanos1A, H. Parmar1B, J.J. Gemmete1B,
C.C. Nelson1A, A. Kahana1A
ADepartment of
Ophthalmology and Visual Sciences,
BNeuroradiology, 1University of Michigan, Ann
Arbor, MI
Session: Glaucoma/Immunology/Microbiology-Risk Factors, Biomarkers, and Blood Flow
Thursday, May 7, 2009 11:15 am - 1:00 pm
Argon Laser Trabeculoplasty (ALT) after Initial Medicine or Surgery in the Collaborative Initial Glaucoma Treatment Study (CIGTS): Predictive Factors and Need for Further Intervention
D.C. Musch1A, L.M. Niziol1A, B.W. Gillespie1B, G.L. Skuta2, P.R. Lichter1A
ADepartment of Ophthalmology & Visual Sciences, BBiostatistics, 1Univ of Michigan, Ann Arbor, MI; 2Ophthalmology, Univ of Oklahoma, Oklahoma City, OK
Session: Retina / Biochemistry & Molecular Biology-Vitreoretinal Surgery
Thursday, May 7, 2009, 11:15 am - 1:00 pm
Complication Rates After Pars
Plana Vitrectomy Among Medicare Beneficiaries
H.M. Grabe1, J.D. Stein1, D.N. Zacks1, D. Grossman2,
M.W. Johnson1, F.A. Sloan2
1Department of
Ophthalmology and Visual Sciences, University of
Michigan, Ann Arbor, MI; 2Center for
Health Policy, Duke University, Durham, NC
Session: Retina / Biochemistry & Molecular Biology-Vitreoretinal Surgery
Thursday, May 7, 2009, 11:15 am - 1:00 pm
Management of Giant Retinal
Tears With Vitrectomy in Phakic Patients
J.A.
Kozak, S.J. Saxe, D.N. Zacks
Department of
Ophthalmology and Visual Sciences, University of
Michigan, Ann Arbor, MI
Session: Retinal Cell Biology/Retina-Müller Cells and Microglia:
Regulate Retinal Protection and Injury
Thursday, May 7, 2009, 1:15 pm - 3:00 pm
Peripapillary “Dark Choroid
Ring” on Fluorescein Angiography Is a Good
Diagnostic Sign in Advanced Stargardt Disease
K.T. Jayasundera, W.R. Rhoades, K. Branham, J.R.
Heckenlively
Department of
Ophthalmology and Visual Sciences, University of
Michigan, Ann Arbor, MI
Workshops
Session: Clinician Scientist Forum - Pitfalls
to Avoid for Developing Clinician-Scientists
Tuesday, May 5, 2009, 12:00 pm - 1:30 pm
Why Be A Clinician-Scientist: Is This
Really For Me?
D.N. Zacks
Department of
Ophthalmology and Visual Sciences, University of
Michigan, Ann Arbor, MI
